Sentence examples for important pathogenic role from inspiring English sources

"We already know that free radical damage has an important pathogenic role in heart disease and stroke," Dr. Perls said, "and it may also play an important role in Alzheimer's disease.

Leukocytes play an important pathogenic role in ischaemia-reperfusion injury.

These advances could contribute to the design of more effective therapeutic strategies for the prevention of diseases, such as atherosclerosis, systemic lupus erythematosus and rheumatoid arthritis, in which the inflammatory process plays an important pathogenic role.

Oxidative stress is believed to play an important pathogenic role in diabetic retinopathy [19].

The PI3K/Akt signaling pathway is deregulated in the majority of human cancers and almost certainly plays an important pathogenic role in carcinogenesis and progression.

Reports showing the clinical resolution of MC and lymphomas after successful interferon antiviral treatment suggest an important pathogenic role for HCV in B-cell dysfunction [12], [13].

We infer that ANXA1 and ANXA2 may play important pathogenic roles in glomerular disorders.

Thus, overexpression of IL-10, TGF-β, and AID in LSGs might play important pathogenic roles in IgG4-RD.

The process of atherosclerosis is mediated by chronic inflammation in which dyslipidemia, hypertension, and diabetes play important pathogenic roles [ 1, 2].

Our results indicate potentially important pathogenic roles of REGγ in multiple cancer types and implicate REGγ as a putative cancer marker.

Our previous study also demonstrated that PEDF binds to LRP6 [ 67], a co-receptor of the Wnt/β-catenin pathway that plays important pathogenic roles in retinal inflammation, neovascularization and vascular leakage in angiogenic eye models [ 67, 87, 131– 131].