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Compelling evidence implicates mitochondrial deficiency, oxidative stress, and inflammation as important pathogenic factors in PD.
These results are viewed as further indication that pre- and peri-natal disturbances of the ventricular system and adjacent neural regions may be important pathogenic factors in schizophrenia.
Conversely, the pelvic obliquity and shoulder girdle rotation were the most important pathogenic factors in hemiplegic children with asymmetrical weight bearing (AS).
Like other plant pathogenic fungi, C. lunata could produce 1,8-dihydroxynaphthalene (DHN) melanin and toxin as two important pathogenic factors to make plant infected.
In HIV patients, an increased incidences of bone fractures has been observed [ 3], and it has been suggested that vitamin D deficiency [ 4, 5] and low bone mineral density [ 6, 7] are important pathogenic factors.
Data published so far have proven that one of the most important pathogenic factors in diabetes onset is a dysregulation of hepatic lipid metabolism, which leads to elevation of hepatic ceramide content [ 35].
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Enterotoxin is an important pathogenic factor in most enteric pathogens, and the ystB gene coded for a class of thermo-resistant enterotoxin in biotype 1A Y. enterocolitica[ 29, 30].
The evidence that NSAID use is an important pathogenic factor in recurrent ulcer disease includes the relationship between NSAIDs and primary PUD, the occurrence of NSAID-induced ulcers in patients taking proton pump inhibitors, and case series demonstrating virulent ulcer disease in patients taking aspirin despite prior acid-reducing operations.
Moreover, multiplication of the wild-type (WT) gene has also been linked to PD, suggesting that the level of α-Syn is an important pathogenic factor [12], [13].
The two genotypes show differences in the expression of an important pathogenic factor: the leukotoxin (ltx).
Furthermore, hyperglycemia induced oxidative stress is an important pathogenic factor in the development of cardiac fibrosis.
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