5. Applying the CBR approach to EHR might be a way to overcome the important obstacles of EHR acceptance and use, providing that technical challenges and ethical issues arising are addressed appropriately.
That HCW do not get vaccinated can be an important obstacle to success of campaigns.
This is confirmed by studies such as that of Drummond et al. [ 10– 12], which revealed that, in the UK, 30% of local decision makers state that being unable to take a long-run view, due to the importance of their annual budget, is an important obstacle to the use of economic evaluations.
Poor permeability and selectivity of the cell membrane are an important obstacle to the development of peptide drugs and therapeutic proteins [ 136] because of the endothelium, which is the first physiological barrier between blood and tissues.
Additionally there is insufficient cooperation between the stakeholders of soil, water and agricultural affairs in the different provinces of the catchment area; this seems to be an important obstacle to the establishment of integrated river basin management.
Lack of adequate antenatal care has been described as an important obstacle to the prevention of congenital syphilis globally, and available data show that this is also the case in Botswana.
However, the absence of requisite infrastructure in the ICU environment is an important obstacle to the adoption of clinical decision-support tools such as those demonstrated to produce a favorable clinical outcome in a multicenter randomized clinical trial [ 5, 6].
These two forms of stress ensue in hypovascular tumor regions and pose an important obstacle to the expansion of cancer cells.
The long-term results of intestinal transplantation are not well known and morbidity remains an important obstacle to wider application of this procedure to patients with short bowel syndrome (SBS).
