Sentence examples for important negative regulators from inspiring English sources
In contrast to Spred1 and Spred2, which regulate developmental lymphangiogenesis, Sprouty2 and Sprouty4 are important negative regulators of developmental angiogenesis in vivo.
The important negative regulators SOCS-1 and SOCS-3 were significantly up-regulated in this study.
These data suggest that, in contrast to Spred1 and Spred2, which are important negative regulators of developmental lymphangiogenesis rather than developmental angiogenesis, as previously reported [18], Sprouty2 and Sprouty4 are important negative regulators of developmental angiogenesis rather than developmental lymphangiogenesis.
These data suggest that Sproutys are physiologically important negative regulators of angiogenesis in vivo and novel therapeutic targets for treating peripheral ischemic diseases.
MafB and IRF-8 are transcription factors that are abundantly expressed in osteoclast precursors and are thought to be important negative regulators of osteoclast differentiation [19], [20].
These data suggest that Sprouty2 and Sprouty4 are important negative regulators of angiogenesis in vivo that could be new therapeutic targets for ischemic diseases.
The tumor suppressor tuberous sclerosis 1 (TSC1) is an important negative regulator of mTOR signaling, which regulates T cell differentiation, function, and trafficking.
For the crosstalk between PI3-kinase/Akt and Notch1 pathways is described that Notch1 signalling via Hes1 down-regulates PTEN, an important negative regulator of PI3-kinase/Akt signalling [ 33].
MKP-1 inactivates p38 MAPK and JNK through dephosphorylation and via NF-κB regulation [46] and functions as an important negative regulator of innate and adaptive immune responses [46], [47], [48].
