Sentence examples for important negative regulator from inspiring English sources

MDM2 is an important negative regulator of the tumor suppressor protein p53 which regulates the expression of many genes including MDM2.

MKP-1 inactivates p38 MAPK and JNK through dephosphorylation and via NF-κB regulation [46] and functions as an important negative regulator of innate and adaptive immune responses [46], [47], [48].

MDM2, an important negative regulator of the p53 tumour suppressor, was up-regulated more than 4 times upon SVCV infection.

LecRK1, which is an important negative regulator of herbivory-induced SA levels is also regulated by SIPK and WIPK ([ 19]; Figure 1).

It is an important negative regulator of FSH release and thus is essentially involved in the regulation of folliculogensis and estrous cycle [ 13].

Protein tyrosine phosphatase-1B (PTP1B) is an important negative regulator of insulin signaling.

These results suggest that insulin, but not IGF-I, constitutes an important negative regulator of CBG liver synthesis.

The N-terminal domain of MDM4 binds to the N-terminal transactivation domain of the tumor suppressor p53 and is an important negative regulator of its transactivation activity.

Conclusions: Cav3 is identified as an important negative regulator for cardiac late INa via nNOS dependent direct S-nitrosylation of SCN5A.

In recent years, PS1 has been identified as an important negative regulator of β-catenin signaling.

It has been shown that AtLSD1 is an important negative regulator of PCD [7].