Sentence examples for important negative growth from inspiring English sources

For these reasons Neu mice offer a relatively well characterized system in which to determine how important negative growth signalling is in opposing mammary cancer formation.

The role of TGF- β1 in SCC is complex and studies suggest that TGF- β1 has biphasic actions on tumour cells, having an important negative growth effect in the early stages of carcinogenesis, but at later stages enhancing invasion and metastasis through epigenetic mechanisms (Akhurst and Balmain, 1999; Akhurst and Derynck, 2001).

These have also demonstrated that TGF-β appears to have biphasic actions on tumour cells, having an important dominant negative growth effect at early stages, but at later stages enhancing the malignant conversion rate and invasion through epigenetic mechanisms.

In summary, the results of this study suggest that myostatin is an important negative regulator of cardiac growth.

However, we have preliminary data suggesting that CIS is an important negative regulator of hematopoietic growth factors, including erythro-poietin, IL-3 and thrombopoietin (A Yoshimura, unpublished data).

These findings assigned let-7b a role as an important negative regulator of melanoma cell growth and proliferation through inhibition of cell-cycle progression.

Whether there is a recession (two quarters of negative growth) is less important than the fact that the economy will operate well below its potential, and unemployment will grow.

For these reasons the strength of oncogenic growth signal is likely an important cue in determining if a negative growth arrest mechanism will need to be overcome during tumor formation.

Here we show that Rb1ΔL/ΔL mice are more prone to mammary tumors in the Wap-p53R172H transgenic background indicating that negative growth regulation is important for tumor suppression in these mice.

Our results implicate WLS as an important negative regulator of human melanoma cell growth and metastasis.

We and others are now showing that Acrp30 may be an important negative regulator of breast cancer cell growth (Miyoshi et al, 2003; Kang et al, 2005; Dieudonne et al, 2006).