Sentence examples for important mutation of from inspiring English sources

In addition, both the short disease course of 5 20 days and high contagiousness implied that highly virulent strains of the PRRSV might be involved in this PRRS outbreak, indicating the likelihood of some important mutation of these strains.

If binding to lipid membrane is biologically important, mutation of the aromatic finger would likely compromise Beclin 1-mediated autophagy.

Recent studies have shown the frequency of codon 146 mutation ranging from 1.0% to 4.0% in CRCs [ 13- 15], however, KRAS mutation at codon 146 is related to resistance to cetuximab plus irinotecan and is recognized to be an important mutation of KRAS gene [ 13].

All of the most important mutations of this population are represented in Table 3.

Many clinically important mutations of BRCA1 gene frequently target these two domains.

Important mutations of these genes are linked to major phenotype alterations and defects, and even lethal conditions.

Mutations in the HLE are therefore expected to provide a valuable control to contrast the catalytically important mutations of H1061 and Y1043 described above.

In this review we are intended to describe the most important polymorphisms at a glance and then the most frequent and important mutations of different populations from all over the world based on the studies which have been freely published online up to April 2013.

We identify the concave, positively charged face of the extended, curved protein shape as functionally important: mutations of conserved basic residues on the concave surface reduce the ability of RecX to inhibit RecA's ATPase and strand-exchange activities and to induce RecA filament depolymerisation.

But her son, who carries the second and more important mutation, has a dulled sense of pain.

The BRCT domains are frequently targeted by clinically important mutations and most of these mutations disrupt the binding surface of the BRCT domains to phosphorylated peptides.