Sentence examples for important mutant from inspiring English sources

The results revealed lead compounds with activity against clinically important mutant kinases, including ALK, LRRK2, RET, and EGFR, as well as unexpected opportunities for repurposing FDA-approved kinase inhibitors as leads for additional indications.

These compounds are active against wild type reverse transcriptase (RT) and retain activity against clinically important mutants.

Unique changes to rice are also sites of potentially important mutants.

A subset of these structurally important mutants consistently appears in most of the examined growth conditions, as shown in the left panel of Figure 4 (filled colored circles).

In order to understand the basis for this resilience at the molecular level and to help the design of further-improved anti-AIDS drugs, we have determined crystal structures of efavirenz and nevirapine with wild-type RT and the clinically important K103N mutant.

Nuclear transport has been reported to be important in mutant Htt pathogenesis, with Htt itself reportedly shuttling between the nucleus and the cytoplasm [10], [13].

Even more important, E1B mutant viruses, such as the present CRAds, exhibited better cytopathic effect on cells in S phase [44].

The immunosuppressive properties of mTOR inhibitors, coupled with their efficacy for tumor prevention in mouse models, suggested that modulation of the immune system is important for mutant K-Ras mediated lung tumorigenesis.

However, TrxR1 appears less important than mutant p53 as a target for APR-246.

In addition, drawing on the collective knowledge of SGD staff and advisors we compiled a list of important early mutant studies in which classes of yeast genes were genetically characterized, such as the cell division cycle (CDC) or sterile (STE) mutants, and added the mutant phenotypes from those papers to the database.

While most of the cancer driver mutations are likely to be rather rare, it is striking that a significant number of functionally important cancer mutants fall at structurally conserved positions within the kinase catalytic core.