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Wnt is an important morphogen in development.
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Wnt1 and Wnt5a are important morphogens for VM development, regulating proliferation, differentiation and survival of DA neurons [15] [24].
Duct formation (DF) is an important process in development and regeneration of many epithelial organs including lung, kidney, mammary glands and liver, and is known to be regulated by diffusible morphogens and elements of the insoluble extracellular matrix [1].
Sonic hedgehog (Shh) is an important morphogen with essential roles in dorsal-ventral patterning during embryogenesis.
Shh is an important morphogen that is secreted at various stages of development.
Sonic Hedgehog protein (Shh) is a morphogen molecule important in embryonic development and in the progression of many cancer types in which it is aberrantly overexpressed.
During early embryonic development, retinoids act as an important morphogen across different species from invertebrate to metazoan including human [ 97, 98].
The above system and resource provide tools to study morphogen function in development.
Other well studied signaling mechanisms involving multicellular signal perception are morphogen gradients in development in many organisms and recently renewed efforts in signals involved in maintaining stem cell niches (some examples reviewed in [52] [56]).
Understanding how the different functions of TGFβ factors are implemented will provide useful insights for morphogen function in development, stem cell maintenance and differentiation, as well as diseases such as cancer.
Nodal is an important morphogen and is required to establish the correct identity of cells in the embryo; for example, it helps determine which cells should become a brain or heart or gut cell and so on.
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