Sentence examples for important molecular changes from inspiring English sources
To initiate this process the epithelial tumor cells must pass through important molecular changes.
While this would hold true for trunk driver events, potentially important molecular changes will be missed if repeat biopsies are not performed during the evolution of the disease.
The human-to-mosquito transmission triggers important molecular changes in the gametocytes, which initiate gametogenesis and prepare the parasite for life-cycle progression in the insect vector.
However, important molecular changes were observed within short periods after Mn exposure, such as the activation of ERK1/2 and JNK1/2/3 signaling pathway.
Our finding that no significant correlation between reduced Apaf-1 expression and tumour thickness favours a multiple-event model that a number of important molecular changes occur sequentially during melanoma progression.
In conclusion, our findings suggest that Fli-1 is an important molecular change significantly related to tumorigenesis and progression of EOC.
More important, the molecular changes associated with this phenotype are surprisingly few, and although the combination of these changes has yet to be found in a field isolate, the mutations themselves are not unique or exclusive to the viruses produced in these two laboratories.
However, because most pericancerous tissue of HCC is cirrhotic, this assumption could miss important basal molecular changes in the cancer microenvironment.
Nonetheless, identifying the similarities in gene expression and genetic pathways through a cross-species approach highlights important conserved molecular changes involved in oncogenesis.
Our study, using a genetic model relevant to early onset AD, shows that clustering of transcriptional profiling data is a powerful method to identify important early molecular changes at the onset of traditional hallmarks of AD.
New, rationally designed early detection, chemoprevention, and therapeutic strategies based on the growing understanding of the molecular changes important to lung cancer are under investigation.
