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One important methodologic difference between this trial and previous studies was the use of DE diaries to ensure that seizure data were recorded on every day of the trial, regardless of whether seizures had occurred.
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Additionally, there may be important methodologic differences between the positive and negative studies that could potentially explain the discrepancy.
A number of studies have evaluated the effects of CO exposure on pregnancy; however a direct comparison of these studies is difficult because of significant methodologic differences.
There are a few important methodologic issues to clarify: 1) How much of the differences in total synthesis rates are due to the kinetic measurements (turnover rates) vs. the tissue concentrations of each metabolite?
Reviewer #2: There are a few important methodologic issues to clarify: 1) How much of the differences in total synthesis rates are due to the kinetic measurements (turnover rates) vs. the tissue concentrations of each metabolite?
It will negate that methodologic difference".
This article describes important methodologic considerations in undertaking a before/after evaluation.
This paper reviews some important methodologic aspects of quotidian dialysis delivery and the outcomes literature in this field, including economics.
Trial registries have the potential to contribute important methodologic information for critical appraisal of study results.
The study has some important methodologic strengths and limitations.
Important methodologic and practical issues still need to be resolved, however.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com