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Hypoxia inducible factor 1α (HIF) and vascular endothelial growth factor (VEGF) are important inducers of neoangiogenesis.
Oxidative stress and elevation of intracellular calcium levels are particularly important inducers of NF-κB activation.
Urine and related pheromones are important inducers of these behaviors [2], [3].
Viral infections are important inducers of seasonal exacerbations of asthma [5], but there is circumstantial evidence that bacterial infections may also play a role.
One of the most important inducers of EMT and tumour metastasis is hypoxia [22] and there is growing evidence of a complex interplay between the AKT/PI3K/mTOR pathway and hypoxia [23] [28].
ROS are important inducers of DNA damage and chromosomal instability.
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TGF-β, an important inducer of EMT, degrades NFI-C, whereas NFI-C induces dephosphorylation of p-Smad2/3, a TGF-β signaling molecule, in odontoblasts and breast cancer cells [ 16].
Furthermore, we identified Nek2 as an important inducer of germinal center formation and showed that high Nek2 induces an immune response through a T cell dependent mechanism.
The induction of S100A8/A9 expression in the pre-metastatic niche that in turn induces expression of SAA family members has emerged as an important inducer of an inflammatory milieu [ 27].
KLF4, an important inducer of MET, activates the epithelial program by triggering E-cadherin expression and induces MET in normal mammary epithelial cells and breast cancer cells [ 35].
The results indicated that IFN-γ was the most important inducer of iNOS in Caco-2 cells.
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