Exact(4)
The variables in the regression model were the group variable, baseline score and the variables demonstrating a potential important imbalance between the groups.
However, the initial duration of mechanical ventilation (MV) was shorter in MIE patients, indicating an important imbalance between groups that may have confounded the difference in outcome.
Our secondary analyses will examine the effect of adjusting for the stratifying factor (type of surgery) or any important prognostic factors that show a clinically important imbalance between groups.
However, in clusters randomized trials, Kerry et al. show that the minimum variance weights are the most efficient weights in the estimation of the design effect in the presence of important imbalance between the clusters sizes, but that weighting the clusters by their sizes give similar – though over estimated – results, except when clusters are large [ 14].
Similar(56)
If there appear to be any important imbalances between randomised groups in terms of baseline covariates, adjusted analyses will also be performed.
For example, in Germany, where there are important imbalances between geographical areas, with the lowest physicians' density in the eastern states, more hospitals look abroad for doctors, particularly in Eastern Europe.
However, there were important imbalances between groups, with more hospital-acquired infections, more need for surgery before ICU admission, and a trend towards more septic shock at ICU admission in the discontinuation group.
In addition, it is important to note the significant imbalance between the patient groups treated with or without concurrent chemotherapy: higher proportion of female patients and higher proportion of patients with stage III NPC received concurrent chemotherapy, as compared to male and patients with stage IVA/B disease.
An important imbalance is observed between the in and out values for the Internet.
Table 2 gives baseline clinical measurements and pre-treatment histopathology/microbiology, according to randomization: there was no clinically important imbalance in measurements between the two groups.
As expected, there were significant imbalances between groups.
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