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One important hallmark for both cancer and stem cells is their self-renewal capability.
UV-induced PAF by activating immune suppression, retarding DNA repair and activating inflammation clearly constitutes an important hallmark for cancer induction.
Among the multiple steps of metastasis, migration of the cancer cells has been recognized as an important hallmark for the successful spread of cancer throughout the body [ 8, 9].
Although the TEWL is an important hallmark for skin barrier function, TEWL is not necessarily correlated with dry skin (Berry et al, 1999; Engelke et al, 1997; Wilhelm et al, 1991).
An important hallmark for myofibroblasts in wound healing as well as in cancer is the expression of differentiation markers such as calponin, desmin and most commonly α-smooth muscle actin (αSMA) (23– 23).
We believe that the total number of cancer cells represented by CEA mRNA rather than the ratio of cancer/noncancer cells (CEA/GAPDH ratio) is a more important hallmark for predicting peritoneal recurrence.
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One of the most important hallmarks for cancers is their deregulated cellular proliferation.
In recent years, epigenetic causes are being considered as important hallmarks for malignant transformation.
Small-interfering RNA (siRNA)–mediated Jund knockdown in WKY BMDMs led to decreased macrophage activation, suggesting a novel role for Jund in macrophage activation, an important hallmark of the pathophysiological features of glomerulonephritis.
Poor differentiation is an important hallmark of cancer cells, and differentiation therapy holds great promise for cancer treatment.
Infiltration of activated neutrophils is an important hallmark of ALI [ 29]; therefore more neutrophils in ALI may account for the high levels of S100A12 in the ALI group.
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CEO of Professional Science Editing for Scientists @ prosciediting.com