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And thanks to the ever-shrinking cost of sequencing, Shapiro can analyze hundreds of individuals per species to learn about important genetic changes.
To address the recognized need for rapid, low-cost diagnosis, tracking critically important genetic changes in the virus among animal and human host populations, and identifying specific viral clades [4], we have developed high-throughput methods for monitoring viral mutations that may control virulence and transmissibility in humans [5].
The most important genetic changes in the cave-restricted Sa are summarized in Fig. 5.
Therefore, the genomic changes are perhaps best regarded as markers of clonal cell populations rather than mechanistically important genetic changes.
This approach avoids missing important genetic changes between BACs but, by definition, overestimates the size of alterations.
Therefore, we propose that the early lesions carry the important genetic changes that reflect the major phenotypic information, while the additional genetic changes accumulated in the invasive carcinoma are less associated with the overall phenotype.
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Background: Integration of human papilloma virus (HPV) 16 DNA is considered an important genetic change in cervical lesion progression towards ICC.
In conclusion, ALK amplification and copy number gain is an important genetic change in CRC and is associated with poor patient outcome.
An important genetic change might have been generated also in the second culture of the evolutionary adaptation, which was characterized by a sharp rise in CO2 evolution at the end, and a dramatic increase in the rate of fermentation when this culture was transferred to the next batch.
The C4-specific kinetic optimization resulted in important parallel genetic changes between the different C4 origins as recently demonstrated for PEPC- and PCK-encoding genes (Christin et al. 2007; Besnard et al. 2009; Christin, Petitpierre, et al. 2009).
It will help document two important sets of genetic changes: those that occurred between 5.7 million years ago, when the human line split from the line leading to chimpanzees, and 300,000 years ago, when Neanderthals and the ancestors of modern humans parted ways; and second, the changes in the human line after it diverged from Neanderthals.
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