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A number of important gene groups that are included in the chip are not mentioned in Table 2.
Several studies have shown that sleep (especially REM sleep) may promote rapid gene transcription, and that several important gene groups are transcribed during sleep., This indicates that while the transcription of some genes is not actively regulated by sleep, this may not be universally true for others.
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FAC1 (pigmentation and melanogenesis) was the most biologically important gene group with enrichment score of 3.54.
In this study, important gene functional groups activated in different seed germination stages were analyzed by MapMan, and the results are shown in Figure 5 and Additional file 2: Table S2.
This indicates that the high correlation obtained is not attributed to individually important genes but rather to gene groups.
Both of these gene groups represent potentially important candidate genes in studying the maternal-to-zygotic transition in T. castaneum.
To compare the performances of unsigned and signed WGCNA in identifying gene groups that are important for the regulation of the pluripotent state, we defined gene modules in unsigned and signed networks and assessed module function and importance by determining gene ontology terms associated with each module and examining module membership of genes known to play a role in ES cells.
Redundancy is a challenge that biologists face increasingly, as large proportions of genes in diverse systems have been found to perform important functions as members of redundant gene groups and, as a result, are often missed in genetic screens (J ohnsen and B aillie 1997; R utherford 2000; G u et al. 2003; F elix and W agner 2008).
Coloured gene groups are indicated.
Additionally, the combinatorial interaction of transcription factors (TFs) is important in regulating the gene group that is associated with the same expression pattern.
The presence of multiple copies of W-boxes in a high percentage of the promoters in the AtWAKL10-ECGG50 indicathatthey they may function as important regulatory elements in the gene group and thus WRKY TFs may be important in regulating the expression of the correlated genes.
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