Sentence examples for important functional effect from inspiring English sources

Pooled data from a series of independent contraction assays using type I collagen gel lattices delineated an important functional effect of this activated phenotype.

Also an important functional effect at protein level of the polymorphism HSP70-HOM +2437 A>G (Met493Thr), affecting the substrate specificity and chaperone activity of HSP-70 HOM, has been described [ 12, 27].

They hypothesise that the variable spacing may influence the degree of Stat-mediated DNA bending and hence have an important functional effect of the transcriptional activation of Stat5a target genes.

This is an important functional effect of treatment since the ability to hold down a job satisfactorily is critical for self-esteem and because, in certain countries such as the USA, remaining in full-time employment is an important determinant of obtaining insurance for reimbursement of treatment costs.

The most important functional effect of this change in the conformation of the bowl is to cause the β2 subunit to move with respect to the two peptide ligand-binding sites such that it is no longer able to block either.

The positively selected sites 194 and 235 (indicated in cyan in Fig.  4) are within these regions, suggesting important functional effects.

Therefore, although we were unable to show that mast cells affect ASM proliferation or survival it remains a possibility that in vivo these interactions may have important functional effects which need to be further defined.

Age-dependent changes in inflammatory cytokine and chemokine production thus have important downstream functional effects.

These data clearly and consistently suggest that RNA editing plays an important functional role in minimizing effect of mutations that would have greatly altered protein structure through amino acid replacement involving drastic changes in hydrophobicity and molecular size.

Furthermore, LDH, a classic marker for cell leakage, was not increased in response to IR. Regardless of its mechanism, it will be important to investigate the functional effect of IR-enhanced LOX levels in the blood on tumor cell dissemination and premetastatic niches [ 27].

In summary, our data show that irradiation of human DC has important functional consequences, with differential effects on DC at different stages of activation.