Sentence examples for important functional changes from inspiring English sources

This makes it difficult to quantify improvement and detect subtle but clinically important functional changes.

This suggests that heteropecilly is driven not only by different fine-grained functional constraints, but also by important functional changes.

Overall, these findings suggest that PEA exerts a key role in regulating astrogliosis and important functional changes, which contribute to disease progression.

Several important functional changes to cancer cell mitochondrial have been observed that implicate the organelle in tumour formation including increased production of reactive oxygen species (ROS), decreased oxidative phosphorylation, and a corresponding increase in glycolysis [ 16, 17].

In spite that the radical changes detected in our study likely produce important functional changes between the OS-E and OS-F proteins, we cannot discard that other detected conservative replacements also have an important adaptive role [see for example [ 53]].

The failure to detect important functional changes in the JIA group in comparison can be explained by the cumulative effects of destructive joint disease in the RA patients who, in most studies, have longer disease duration and sub-optimal drug management.

A further very important functional change after vascular injury includes the phenotypic modulation of VSMCs.

The finding that patients reported clinically significant functional changes through 2 years is important to highlight.

It is likely that the observed metabolic changes reflect important functional protein changes that may additionally play an importantly role in the maintenance of hESCs in vitro.

A critical window is defined as a period of important structural and functional changes during normal organ development when exposure to certain environmental changes may originate life-time consequences [1].

Since tumours undergo changes in metabolism before apparent changes in size, it is important to evaluate functional changes as early as possible during treatment.