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We also reported that VLA-3 is important for the initial penetration of leukocytes into the endothelial basement membrane.
At the beginning of the season, flood events are critically important for the initial water supply to the ponds.
Heterogeneous nucleation is very important for the initial droplet formation of dropwise condensation, and it is directly related with the surface properties of materials.
Muscle IL-6 expression appears important for the initial growth response during the recovery from disuse.
This argues against gp150 being important for the initial capture of virions onto cell surfaces.
As proposed for Man-binding, Neu5Ac may be important for the initial contact between environmental C. jejuni and host tissues.
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Additionally, I showed for the first time that another conserved histidine, at position 48 in Npu, is important for both the initial steps of the reaction (branched intermediate formation) and even more so for completion of splicing (branched intermediate resolution).
Comparison of TdPI with a shortened variant lacking the flexible prehead and posthead segments revealed that these regions do not contribute to the protein conformational stability or the inhibition of trypsin but are important for both the initial steps of the folding reaction and the inhibition of tryptase β.
Moreover, Tsung et al. showed in a model of hepatic I/R injury that functional TLR4 signaling in non-parenchymal cells in particular is important for recognizing the initial damage from ischemic cells.
The emerging picture is that the immune response to infection with F. tularensis involves IFN-γ and TNF-mediated activation of resident macrophages and recruited neutrophils that are important for controlling the initial infection, and CD4+ and CD8+ T cells that are required to fully resolve the infection and produce long-term protective immunity (reviewed in [14]).
However, psychosocial factors are also believed to be important for both the initial development of MSDs and the long-term disability that may follow [ 18– 22].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com