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Understanding of the characteristics of soil organic matter (SOM) and soil nutrients at the field and catchment scale is important for refining agricultural management practices and for improving sustainable land use.
Whereas the report by Lee et al. [ 4] is potentially important for refining the spectrum of MPS symptoms, our study presents new data casting doubt on the pathogenicity of RAB40AL p.D59G in MPS.
Species information including the presence of threatened species is important for refining conservation priorities, such as the designation of critical habitat, no-take zones, or marine protected areas, or to inform policies that regulate resource extraction or coastal development.
However, as a population approaches sufficiency, accurate estimation becomes more important for refining programmes.
This data will be important for refining models of HPV infection and cervical disease to inform the renewal of Australia's national cervical screening program [ 36].
These data support previous in vivo studies of pre-implantation stage embryos [ 13, 14], showing that dynamic changes in chromatin occur at the earliest stages of mammalian development and are likely to be important for refining cellular potential.
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Therefore, stability has become an important method for refining the Nash equilibrium ([14, 21 26]).
This work further contributes to improved understanding of sulfur and oxygen isotope systematics in shallow-sea hydrothermal systems and associated interactions with the ocean, with important consequences for refining global biogeochemical budgets [59],[60] and for providing modern analogs for evolving chemistry of the ancient ocean [61],[61].
LeishCyc is therefore likely to constitute an important resource for refining metabolic reconstructions in the future.
Microfluidic, cellular co-cultures that approximate macro-scale biology are important tools for refining the in vitro study of organ-level function and disease.
In addition, ordered arrays of BAC clones will be an important resource for refining the comparative cytogenetic data within the diverse karyotypes that comprise the Canidae.
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