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Like PAG, CTLA4 is also reported to function from lipid rafts [ 32- 34]; a membrane compartment that is important for propagating TCR signals.
The faculty head viewed undergraduate research as important for propagating the research community and for gaining insights into undergraduates and their postgraduate mentors.
The kinetics governing covalent modification cycles in a signaling network were more important for propagating an upstream off-target effect in our models than the kinetics governing the targeted therapy itself.
This result suggests that the activity and efficiency of component cycles in the network may be more important for propagating an off-target effect than the actual kinetics of a targeted therapy.
A crucial finding of this work is that the kinetics governing the covalently modified cycles in a signaling network are likely to be far more important for propagating an off-target effect due to retroactive signaling than the binding affinity of the drug for the targeted protein, which is a commonly optimized property in drug development.
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This "selfish cluster" hypothesis postulates that horizontal gene transfer is an important mechanism for propagating and maintaining gene clusters in eukaryotes, reminiscent of the "selfish operon" hypothesis proposed in prokaryotes [ 56].
Studies on cultured mammalian cells have shown that formation of a reticular mitochondrial network is important for proper mitochondrial calcium buffering and for propagating intra-mitochondrial Ca2+ waves [11], [12].
One of the important issues in uncertainty analysis is to find an effective way for propagating uncertainty through the system.
That gives us an alternate path for propagating living organisms.
Campaigners condemned the rapper for propagating views that "amplify" the conditions in which rape is normalised.
Such misinformation can have serious consequences, and Fox News should be called out for propagating it.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com