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The cysteine directs protein prenylation important for localisation of the PRLs.
The placement of radio-opaque clips in the tumour bed prior to commencement of chemotherapy is important for localisation for breast conserving surgery, and has been shown to reduce local recurrence rates (Oh et al, 2007).
These results demonstrate that the Glu residue is also important for localisation of GFP-BtpA, and suggest in addition that negative charge at this position is essential for the ability of BtpA to protect microtubules from degradation.
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These in vivo data strongly suggest that myosin Va is important for the localisation of rapsyn-GFP and that it is likely implicated in processes concerning internalisation of NMJ components.
Thus, phosphorylation of HuR is important for its localisation in the cells.
SopB can also bind Cdc42 through its N-terminal, and this too appears to be important for SopB localisation to the SCV and its spatial regulation.
In D. melanogaster ERM1 is important for Osk localisation [ 185], but clearly it cannot function in this way in P. aegeria, which lacks Osk.
The predicted Gpd proteins from A. pullulans lack the N-terminal PTS2 sequence that is important for peroxisome localisation, a trait also noted in other halotolerant fungi [ 92].
An appreciation of the normal variants in venous anatomy, and meticulous tracing of the paths of intra-hepatic veins are important for accurate localisation of disease in the hepatic segments.
PAR1 is known to be important for Delta ligand localisation in Drosophila [21], so we speculate that the failure in MARK (mammalian homologue of PAR1) activation in the absence of Lkb1 may directly lead to the lack of Delta ligand in Lkb1-deficient Paneth and goblet cells and subsequent deregulation of secretory cell differentiation.
This study showed that the FYVE domain of SPASTIZIN is important for its lysosomal localisation, which strongly supports our data showing PI(3 P at the lysosome.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com