This is an important flaw of the simulation procedure because once a split is present in the network, it will increase sensitivity (or decrease PPV) of the method, even if the weight of this split is vanishingly small.
The peer-review referee comments are available on Tol's blog, saying for example, "Rather than contribute to the discussion, the paper instead seems oriented at casting doubt on the Cook paper, which is not appropriate to a peer-reviewed venue, and has a number of important flaws..
The meta-analysis described a number of important flaws in the literature which caused difficulty in aggregating the individual study findings.
Nouriel Roubini: That was actually, absolutely one of the important flaws.
The last COSMIN item (COSMIN requirement 5) determines whether there are any important flaws in the design or methods of the study.
Thus, it is possible that studies at low risk of bias have important flaws with respect to methodology and/or reporting (and vice versa), and it is possible that using other scales to assess study quality could have led to different results.
Other important flaws in the automatically generated C. difficile network include the presence of 1562 export reactions and 648 dead-end metabolites.
The description of each domain provides a general risk of bias in the included randomized trials as well as any important flaws in the studies [1].
There are several important flaws in this analysis.
There is one important flaw -- as of right now, the voice call quality is mediocre.
