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H3K14ac (acetylation of lysine 14 of histone H3) is one of the most important epigenetic modifications in cells.
DNA methylation is one of the most important epigenetic modifications.
DNA methylation and histone modifications are important epigenetic modifications associated with gene (dys)regulation.
DNA methylation is considered one of the most important epigenetic modifications in eukaryotes.
Thus, as the important epigenetic modifications, DNA methylation and chromatin modifications contributed to the epigenetic disorders of T2D together.
The most important epigenetic modifications of mammalian cells are associated to DNA methylation, posttranslational histone modifications, and to a class of short noncoding RNAs, the microRNAs (miRNAs or miRs) [ 6, 9].
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DNA methylation is an important epigenetic modification involved in many biological processes and diseases.
Histone lysine methylation is an important epigenetic modification with both activating and repressive roles in gene expression.
DNA methylation is a fundamentally important epigenetic modification of the mammalian genome that has widespread influences on gene expression.
Histone acetylation is an important epigenetic modification which subsequently can affect chromatin remodeling, e.g. via bromodomain proteins.
DNA methylation is an important epigenetic modification that leads to a wide variety of biological functions, including transcription, growth and development, and diseases associated with altered gene expression such as cancers.
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