Sentence examples for important epigenetic changes from inspiring English sources

Mutational-driven comparison with other tumor types showed that UM is very similar to pediatric tumors, characterized by very few somatic insults and, possibly, important epigenetic changes.

Although the female gamete is blocked at the dictyate stage of the first meiotic prophase during the whole folliculogenesis, many important epigenetic changes occur to organise the genome to attend early embryonic development.

It has been substantially shown that DNA methylation plays a pivotal role in the regulation of DNA transcription level [ 9], and DNA methylation is one of the most important epigenetic changes [ 7].

Current information suggests that skin tumor promoters are not mutagenic but bring about a number of important epigenetic changes, such as epidermal hyperplasia, and an increase in polyamines, prostaglandins and dark basal keratinocytes as well as other embryonic conditions.

Alterations in histone-controlled chromatin structure are important epigenetic changes elicited by many toxicants (Bagnyukova et al. 2008; Moggs and Orphanides 2004); therefore, we examined the effect of BD on the extent of methylation of histones H3K9, H3K27, and H4K20.

Histone acetylation is an important epigenetic modification.

The environment is particularly important for epigenetic changes driving disease, with accumulating evidence that the epigenome may be important in allergic disease [ 66].

(1) neonatal microsomia is not always a risk factor for adult metabolic syndrome, (2) neonatal non-genetic microsomia displays changes in the expression of important epigenetic genes and changes in liver mRNA transcription profile at birth, exaggerating sexual dimorphism, and (3) random preimplantation phenotypic variability could partially explain body birth weight variation in isogenic lines.

Child environment, an early stress and the mother-child relationship are important factors of epigenetic changes in the pathogenesis of migraine [42].

However, cautious interpretation of the results is important because actual epigenetic changes in schizophrenic patients may represent changes in methylation status [ 50].

Important alterations encompassing epigenetic changes are DNA methylation and RNA-based mechanisms including those controlled by microRNAs (miRNA) and long intergenic non-coding RNAs (linc-RNA).