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Furthermore, we definitively show the role of type I interferon in RV infection in vivo and its importance in controlling RV replication and RV driven inflammation, important endpoints in human exacerbations of asthma.
In this study, we calculated the percentage of positive studies with several of important endpoints.
Identification of the most important endpoints: This was carried out not by the QSAR modellers, but by the stakeholders.
Larger, well-designed randomized controlled trials with clinically important endpoints in specific populations of AF patients are needed.
In this article we also discuss our strategy of statistically correlating individual gene expression with biologically important endpoints designed to address the problem of evaluating functional relevance.
The way in which the directive inspired the work can be summarised as follows: Identification of the most important endpoints: This was carried out not by the QSAR modellers, but by the stakeholders.
In the sense of the presented test strategy, most important endpoints to be considered include further (a) biotic transformation/degradation, mobility and transport in porous media, and sorption to soil, sediment and sludge of the pristine and aged ENM.
However, the available studies are limited by an inadequate consideration of some of the most important endpoints in chronic headache research, namely the frequency of headache and the consumption of medications for acute headaches management.
These stem from the fact that the underlying mechanisms and clinical manifestations of heart failure in children are heterogenous, clinical outcome measures have not been well characterized, and the power to detect clinically important endpoints is limited by the small number of affected patients.
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Issues of safety must be assessed in well-powered RCTs with patient-important endpoints such as persistent organ failure, mortality and quality of life.
Guidelines can be helpful in clinical decision making, provided that they have been developed following rigorous methodology and provided that they address clinically and patient-important endpoints (Guyatt et al. 2008b).
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