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The importance of dyspnoea is recognized by regulatory agencies and accepted as an important endpoint required for registration trials of new AHF medical treatments, provided there is sufficient evidence of safety.
Response remains an important endpoint in clinical cancer trials.
One important endpoint of the MEOGRT is fecundity of medaka breeding pairs.
This study will evaluate this important endpoint in the context of bisphenol-induced neurotoxicity and can inform public health policy.
For mineral particles such as crystalline silica and mineral fibers, an important endpoint is their potential carcinogenicity.
One important endpoint to be measured in future studies is MRD negativity in standard or high-risk disease, since it is a significant predictor of PFS, OS, and potential cure in a fraction of patients109.
Reduced sulphur species represented the most important endpoint for these NPs in the sewer with slight differences in terms of speciation; ZnO converted largely to Zn sulfide, while Ag was also sorbed to cysteine and histidine.
"If F.D.A. sets a precedent of approving a drug based on progression-free survival, people are afraid they may stop looking at survival as the most important endpoint," said Dr. Kay Dickersin, director of the Center for Clinical Trials at Johns Hopkins University.
But further analysis of the results seemed to show a benefit in lung function, a far more important endpoint.
Clinical studies have increasingly incorporated HRQoL as an important endpoint to understanding patient care experiences.
This important endpoint is more problematic to assess than other endpoints [2].
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