This may be important in some species like Caenorhabditis elegans where there is significant editing of 3′UTRs.
glp-4 (bn2 ts ) G296D lies just inside a region of the valyl-tRNA synthetase called the CP1 domain, a region that links the Rossman-fold of class I tRNA synthetases to the editing domain (Fukai et al. 2000), and plays an important editing role of its own for the isoleucyl, leucyl, and valyl-tRNA synthetases (Chen et al. 2000; Sarkar et al. 2007).
HL, RK, SP, MBF, SYD, MEH, AJR, MGH and CEW designed the research approach; HL, SP, MBF, SYD, XG, AM, and JMY performed the research; all authors analyzed or interpreted data; all authors drafted or provided important edits to various parts of the paper; HL, RK, MGH and CEW revised the overall paper.
In our study, the GluR2 Q/R site, the most important editing site for modulation of AMPA receptor channel properties, remained fully edited after KA injection in both the brain areas analyzed, indicating that modifications in calcium permeability of AMPA receptors were not involved in KA action.
'Millions of Britons now have access to all of Wikipedia, and volunteers can resume their important editing work.' Any outbreak of sweetness and light is welcome in these gloomy times, but the episode highlights an issue most of us would prefer not to have to think about: who actually controls the net?
A revised abstract and list of important edits are indicated below.
Both practices are important, but heavy editing of early drafts may reduce the likelihood of further substantial revision.
KN contributed to study design, critical revision of the article for important intellectual content, editing of the paper, and final approval of the version to be published.
MZ contributed to interpretation of the results, critical revision of the article for important intellectual content, editing of the paper and final approval of the version to be published.
Collectively, these observations suggest that mC to T mutations outside the canonical mCG sites may play an important role in continuous editing of TE-derived sequences in primate genomes.
