Sentence examples for important downstream signalling from inspiring English sources
In this study, we investigated the expression and prognostic value of EGFR, EGFR variant III (EGFRvIII), HER-2/neu and important downstream signalling components in a large series of epithelial ovarian cancer patients.
It has been reported that once deposited into the ECM, VEGF binds to its receptor VEGFR2, which can trigger the phosphorylation of VEGFR2 at Tyr the activation of Akt and the activation of ERK1/2, important downstream signalling events, which require association of VEGFR2 with β1 integrin.
It is believed that PI3K/Akt is among the most important downstream signalling pathways and that VEGF is one of the most important modulators of effects.
Moreover, our studies support a link between aberrant cytoskeleton organization and regulation of important downstream signaling events that may be involved in cancer progression.
Phosphorylation of Akt and p70S6 kinase (p70S6K), two important downstream signaling factors, was also significantly increased indicating a general enhancement of PI3K/Akt signaling pathway in InsR silenced cells.
Consistent with this observation, there was a reduction in inducible tyrosine phosphorylation of important downstream signaling molecules, such as Syk and PLCγ2.
Syk is an important downstream signal molecular of moesin (Urzainqui et al., 2002; Matsumoto and Hirata, 2016) and can regulate calcium signaling in several immune cells (Kulathu et al., 2008; Krishnan et al., 2009).
Beside MAPK signal pathway, NF-κB pathway is the most important downstream signal transduction pathway mediated by LPS [24] [27].
Meanwhile, JNK is an important downstream signal of the endoplasmic reticulum stress (ERS) response.
The important downstream signaling of c-Met includes the MAPK cascade and PI3K/Akt signaling pathway, which mainly regulates cell proliferation and motility [ 3].
