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Perhaps the most important disruption is that the cost of leads in such a batch process suddenly becomes independent of their number.
The first sign that an important disruption is occurring is the incumbent writing off the new innovation as just a toy.
More important, disruption of the pro-apoptotic protein provided a long term protection and preservation of the OS and ONL, still effective in older mice at 12 months of age.
Analysis of residual tissues indicated an important disruption of collagen architecture and a decrease in CAF, albeit the number of activated CAF remained unchanged.
Consistent to our computational identification that NF-κB inducible transcription of Nfkb2 is important, disruption of NF-κB-inducible synthesis by expressing p100 from a constitutive promoter in Nfkb2 −/− MEFs abrogated crosstalk amplification of TLR4-induced late NF-κB activity by concomitant LTβR signal.
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Recent pathological investigations of bats dying from WNS in North America led Cryan et al. [50] to propose that mortality was caused by important disruptions of wing-dependant physiological functions due to infection by G. destructans.
Remember though, important disruptions such as dangerous or priority interruptions warrant instant attention.
The landform characteristics associated with the road network produced an important hydrogeomorphic disruption in the landscape.
In addition, the cleaved ROCK1 fragment appears to be important for disruption of nuclear integrity and the packaging of fragmented DNA into membrane blebs and apoptotic bodies.
An 11 amino acid stretch of the N-terminus of the acidic region (32 42) was shown to be important for disruption of the phagosome.
We reason that if PUs are biologically important, such disruptions should be avoided.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com