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PRC2 is involved in a number of important developmental transitions.
Putative HCNE peak targets are characterized by a tight association with particular promoter motifs, higher incidence of severe mutant phenotypes, and evidence of a more precise regulation of gene expression during important developmental transitions.
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The snap-point thus defines an important developmental transition from cell elongation to cell wall thickening.
Thus, formation of 5hmC promotes neuronal differentiation by modulating the expression of genes most critical in this important developmental transition.
The longitudinal perspective in this study captures an important developmental transition from dependent childhood to early adulthood when considerable, if not complete, independence is expected [ 49].
The lack of studies focusing on these histone turnover events greatly hampers insight into its relation to histone clipping, for the latter process seems to be associated mainly with differentiation, which equally is an important developmental transition.
Despite these early insights, prior forays into gene expression profiling of this important developmental transition generally lacked the temporal resolution required to extend the undoubtedly primitive two-stage model of mammary involution.
This new school context constitutes an important developmental transition, which is associated with changes in social roles and a substantial reorganization of attitudes and beliefs and has been considered a period of risk for problematic behavior [ 48].
Another important developmental transition involves global DNA demethylation in primordial germ cells (PGCs) that commences at around embryonic day 8.5 to 9.5 and is completed near embryonic day 13.5.
The transition into adulthood can be regarded as a second crucial developmental transition point.
In Arabidopsis thaliana, it plays an important role in developmental transitions (Farrona et al. 2008; Bouyer et al. 2011).
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