Burnout, found in front-line human services workers, has important deleterious effects on job satisfaction, nurse turnover, patient satisfaction [ 27].
Theoretically, polymorphisms represent sequence variations, which are present in the general population and confer no obvious or important deleterious effects.
Zerovalent iron NPs, however, have been shown to remove oxygen from and alter pH ground-waters, important deleterious effects resulting in unanticipated environmental impacts.
The confidence intervals rule out any important deleterious effects of the intervention but the precision attained leaves equivocal results as to whether there is a clinically important benefit from the intervention.
Thus, many of the most important deleterious effects of CRT in humans are paralleled in Drosophila, suggesting that the Drosophila model can be useful in elucidating key genetic mechanisms responsible for the neurotoxic effects of radiation that are likely to be conserved between flies and humans.
Despite some controversy, the prevailing view in the scientific community is that BPA has important, deleterious effects in animals by acting on multiple target tissues (reviewed by Rubin 2011; Taylor et al. 2011), and BPA levels have been associated with adverse health outcomes in humans (Lang et al. 2008).
It has been shown that housekeeping genes may be particularly confined to chromosome regions possessing the appropriate transcriptional environment; indeed, mutations that alter their location may exert important deleterious pleiotropic effects in diverse tissues and developmental stages (Wang and Zhang 2010).
We conjecture that these robust dysregulations in cultured HPRT-deficient cells may have important neurologically deleterious effects in the human disease.
Doxorubicin (DOXO), a widespread anti-cancer agent, has clinical limited use due to important deleterious cardiac side effects that ultimately lead to heart failure (HF).
