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The most important culprit is almost certainly the overconsumption of protein.
When sober histories are written about Limbaugh, they will not describe him as a potent intellect but as the most important culprit in the dumbing-down of American political discourse in the post-Reagan period.
MIF may not turn out to be the most important culprit responsible for septic shock syndrome, cautions Thomas Martin of the University of Washington in Seattle, but he says that antibodies against MIF are "a new player that needs to be tested in humans".
Numerous independent studies have reported the specific overrepresentation of AIEC species in biopsies from patients with CD, ulcerative colitis and colon cancer, thus pointing to this pathotype as an important culprit in determining the onset and perpetuation of inflammatory bowel diseases [5] [13].
Thus, our findings suggest that flagellin might represent an important culprit of these changes in this setting.
"But an equally important culprit has been the unbridled growth in the Southeast in the past 50 years [where the] abundance of cheap water has long fueled development".
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Interruptions of EN for procedures, emesis, high gastric residual volumes (GRVs), diarrhoea and feeding tube replacement are important culprits [ 6].
Fraud is an important, though unquantified, culprit.
West Cornwall Liberal Democrat MP Andrew George said: "It is important that the culprit responsible for this incident is tracked down and prosecuted".
As important as finding the culprit is the uncovering of the causes that contributed to this heinous act.
Whole exome sequencing is emerging as an important tool for identifying culprit genes in inherited arrhythmia disorders, and has been useful in identifying candidate genes in arrhythmogenesis.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com