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A new design of experiments technique is developed, whose key issue is the search of the important control points.
These irreversible steps, phosphorylation of glucose, phosphorylation of fructose-6-phosphate, and transfer of phosphate to phosphoenolpyruvate and then to ADP, would be the most important control points.
Several of these pertain to events which have previously been recognized as important control points: ribosome synthesis and translation initiation, for example, are generally considered to limit the speed of cell growth and are implicated in oncogenesis [13].
Parameters describing important control points at the complex 1 and 2, the Bim/Bid module, the phosphorylation of JNK and the the NF-κB module show a much less robust behaviour.
Hemopoietic progenitor cells and stromal cells are important control points for regulation of hemopoiesis.
Further, our results suggest that nodes may be important control points for photoassimilate distribution in crops of the family Poaceae.
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It is therefore an important control point in the system of cellular energy release.
Costimulation is an important control point to ensure that professional APCs define initiation, differentiation, and persistence of T cell responses.
Altered regulation and susceptibility to apoptosis will not only have consequences to the investigation of this critical biological function but will have more widespread consequences for the investigation of macrophage function, since regulation by apoptosis is an important control point over function [20], [31].
The total levels of Dicer may serve as an important control point in miRNA biogenesis.
This complex is known to be an important control point in the citric acid cycle.
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