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The most important concern has surrounded cancer as the field of epigenetics has been studied largely in the context of tumorogenesis where clear DNA methylation pattern changes in tumors have been reported [39 44].
But this important concern has more to do with the environment, parameters, methodologies, and goals of teaching and curricular design.
Our first and most important concern has been that an identification problem must be defined unambiguously as an optimization problem.
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Recent evidence suggests that although drug-eluting stent (DES) have reduced restenosis rates, important concerns have been raised regarding increased late stent thrombosis, myocardial infarction and death.
However, as highlighted above, important concerns have been raised about the long-term safety of these agents.
Important concerns have also been raised recently about the relationship between self-reported measures of confidence 40 and clinical performance.
However, important concerns have recently been raised regarding the potential cardiovascular toxicity of the entire NSAID class, including selective and nonselective agents [ 12- 14].
The Prostate, Lung, Colorectal, and Ovarian Screening trial (PLCO) in the US did not find an advantage to screening at a median follow-up of seven years, 1 although important concerns have been raised as to the widespread use of prostate specific antigen testing in the control arm of this trial.
Because objectivity is one of science's most important goals, this concern has considerable merit.
3) My most important concern, however, has to do with rising energy prices.
Computational efficiency is therefore an important concern and has motivated research in many types of approximate or optimized methods (see for example [ 23- 27]).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com