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GSTs have long been known as important components of cellular defense mechanisms in mammalian systems [2] and recent studies are revealing their significance in mediating allelochemical tolerance in invertebrate-host interactions (reviewed in [3]).
There is compelling evidence that the death receptor signaling proteins TRADD, FADD, and caspase-8 are important components of cellular responses to cytoplasmic dsRNA.
This may be related to the change in the structure and biochemical properties of the lipid that provides important components of cellular membranes and protection from oxidative stress, particularly in the central nervous system where omega-3s are concentrated in nervous tissues.
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Focal adhesion kinase is an intracellular protein kinase that plays critical roles in cell migration, focal adhesion formation, and is an important component of cellular mechanotransduction.
In these physiologically normal tissues, P-gp is important in the transport of steroids, the efflux of toxic molecules, the production of bile, and is an important component of cellular defense and protection [40], [41].
Carriers are an important component of cellular biochemistry (and of biotechnological production [ 66]), with many hundreds known in both yeast [ 67] and human [ 68, 69] cells.
Apical secretion is an important component of cellular invasion and maintenance of this polarization is thus vital to the survival of the parasite.
Because HO-1 is an important component of cellular defenses against oxidative stress, we assessed whether non-cytotoxic concentrations of SHME would affect HO-1 protein expression.
An important component of cellular defence is the expression and regulation of proteolytic enzymes [ 39], and we find that variability in the expression of genes encoding this function is over-represented (Table 3).
With respect to TP53 it plays at least 2 separate roles in the responses to therapeutic agents: it is an important component of cellular checkpoints, and it can mediate apoptosis.
These proteins are important components of the cellular antioxidant system, and their inhibition contributes to the disruption of the normal redox balance of cells [ 7].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com