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Exact(11)
A 3.5-day cycle time was chosen because it approximates the time of important clinical changes.
By targeting to the disease, measures are more likely to be sensitive to small but important clinical changes.
The criteria of minimally important clinical changes will be established by cross-validation of the different assessment instruments.
Further, the requirement for a useful outcome measure is the responsiveness in detecting small but important clinical changes of quality of life in patients following vascular interventions [ 13].
Disease-specific scales are required to discriminate between levels of severity of conditions or diseases and to detect important clinical changes.
The study was small and underpowered to observe important clinical changes following allergen challenge to associate with the granulocyte trafficking, but does provide confidence for further clinical development.
Similar(49)
The Disability Scale assesses self-perceived disability, has favourable levels of ordinal categories, a change in categories imply important clinical change, and high concurrent correlation with the DHI-N indicates similar functional constructs.
For 9 out of the 15 QOL domains covered by the QLQ-C30 the differences between the assessment at the day of CT and one week later exceeded the threshold for a minimal important clinical change [ 11], with strongest increase in burden found for Fatigue, Constipation, and Appetite Loss.
This may indicate an important positive clinical change in quality of life.
A reliable assessment of grip strength is important to capture clinical changes in interventional studies.
As surgery is primarily aimed at releasing contracted tissues and splints designed to maintain this extension, total extension deficit is an important clinical measure of change and a more proximate outcome.
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