Sentence examples for important checkpoint for from inspiring English sources

The nuclear capping reaction serves as an important checkpoint for RNA quality control.

Thus, the fine balance between Bim and Bcl-2/Bcl-xl expression levels represents an important checkpoint for cell survival.

Consequently, recruitment of active P-TEFb to the paused polymerase complex serves as an important checkpoint for gene expression (Levine, 2012; Luo et al., 2012b; Zhou et al., 2012).

The secondary structures and the highly conserved regions became important checkpoints for the multiple sequence alignment.

Here, we chose two genes: DNA-PKcs (an essential factor for non-homologous end-joining repair) and ATM (an important checkpoint regulator for promoting homologous recombination repair) as the targets to search their regulating miRNAs.

CDC25s are important checkpoint regulators for handling DNA damage caused by UV light, ionizing irradiation, or chemicals in eukaryotic cells.

Following DNA damage, Che-1 is phosphorylated by MK2, another important checkpoint kinase, and this modification is required for nuclear translocation of Che-1.

In this model, basal activation of MAPK by FGF-2 is an important antagonistic checkpoint for regulation of TGF-β signals.

This interaction is important for checkpoint activity [ 17], and in human cells, the RLK motif is required for kinetochore localization of Mad1 [ 12].

Thus, we conclude that this C-terminal region of Chk1 is important for checkpoint function and predict that a limiting factor capable of associating with Chk1D469G, but not Chk1D469A, interacts with Chk1 to elicit checkpoint activation in response to a subset of DNA lesions.

We conclude that the C-terminus of Mad1 (with the RLK motif) and Bub1-cm1 are involved in recruiting Mad1 to kinetochores and both regions are important for checkpoint function.