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Working on tuna heart tissues in the lab, they have detailed how PAHs can block important cellular pathways.
P53 is a transcription factor and known tumor suppressor that regulates many important cellular pathways, including cell survival, DNA repair, apoptosis, and senescence (Bensaad et al., 2009).
In both prokaryotes and eukaryotes, small RNAs act post-transcriptionally, regulating a myriad of important cellular pathways (for reviews see refs. [31] [35]).
[Ca 2+]i regulates important cellular pathways, including those leading to cell death by apoptosis or necrosis, therefore, modulation of [Ca 2+]i constitutes one of the most widely used cell signalling mechanisms.
This might lead to uncoupling of important cellular pathways.
It is also related to repair and proliferation among other important cellular pathways [63,64].
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Fas/FasL signaling is an important cellular pathway in the induction of lung epithelial cell apoptosis in ALI.
Situated at the interface between DNA damage signaling and the ubiquitin system, viruses can reveal key convergence points in this important cellular pathway.
The Fas/Fas ligand pathway has been implicated as an important cellular pathway mediating apoptosis in diverse cell types [52].
Our study indicated that the TLR9 signaling pathway constitute an important cellular pathway mediating this interaction in glioma, however, other independent retrospective and prospective studies will be necessary before direct clinical application of the current findings.
Fas/Fas ligand (FasL) signaling has emerged as an important cellular pathway regulating the induction of apoptosis in a wide variety of tissues as well as activated immune cells [ 10, 11], thus playing a crucial role in the resolution of inflammatory responses [ 9].
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