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Homologous regions likely play important cellular functions and thus are preserved through evolution; hence, homologous regions are likely rich in therapeutic targets.
Many of them have important cellular functions, and often functions are directly related to secondary and tertiary structure.
The proteins in our dataset control very important cellular functions and one might expect to find signals of strong purifying selection, to the contrary we observe high levels of both non-adaptive and adaptive evolutionary events in the data.
CLL appears to be similar to other hematologic malignancies whose pathogenesis involves structural changes on the chromosomal level that cause mutational changes on the molecular level, altering important cellular functions, and, ultimately, leading to malignant transformation of a cell (Irons and Stillman 1996).
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Due to its important cellular function and repeated reports of its dysregulation in FD cells, it would be very interesting to test TMEPAI in further studies.
Overall, our results suggest that the numerous TE exaptations already described might just be the tip of the iceberg, and highlight the role of TEs as raw material for the recurrent evolution of important cellular functions (Bowen and Jordan 2007; Sinzelle et al. 2009).
The endoplasmic reticulum (ER) is an organelle responsible for several important cellular functions including protein and lipid biosynthesis, Ca2+ storage, and signaling.
The tripeptide glutathione can potentially fulfill two important cellular functions; metal sequestration and oxidative detoxification [54].
The ER is one of the most important membranous organelles in cells and is involved in many important cellular functions including protein folding and transportation, lipid synthesis, and maintaining calcium homeostasis [ 8].
ABC transporters are a large group of proteins which have roles in important cellular functions such as import and export of various substances including iron chelators (siderophores) [23].
Riboswitches and ribozymes are widespread in nature, and mediate important cellular functions such as replication, RNA processing, and protein synthesis.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com