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Primary human T lymphocytes represent an important cell population for adoptive immunotherapies, including chimeric-antigen and T-cell receptor applications, as they have the capability to eliminate non-self, virus-infected and tumor cells.
These studies demonstrate the utility, flexibility, and biological activity of this MMP-degradable system for the characterization of VICs, an important cell population for tissue engineering viable valve replacements and understanding valvular pathobiology.
Macrophages are an important cell population for the innate immune response and might also be involved in the regulation of acquired immune responses [ 29].
In addition, GC-1 cells express G protein coupled receptor 30 (GPR30), which mediates a rapid xenoestrogen-activated pathway in premeiotic germ cells, among which spermatogonia represent the most important cell population.
Macrophages represent the most important cell population throughout the first days after injury, being responsible not only for the removal of cellular debris and apoptotic cells but also for the release of specific cytokines.
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In conclusion, this Ad targeting approach provides a novel way to circumvent the problem of structural and biosynthetic incompatibility between Ad and complex targeting ligands, and could facilitate Ad targeting to a wide variety of clinically important cell populations using novel targeting ligands including recombinant antibodies and growth factors.
The most important cell populations involved in angiogenesis are hematopoietic progenitor cells (CD133+, CD117+, and CD34+) and MSCs, which are CD34 negative.
NK cells are one of the most important cell populations of innate immune system with diverse effectors functions like killing the tumor cells and virus-infected cells as well as secreting various cytokines.
This study demonstrates that testicular tissue and cells from sexual reassignment patients can be successfully cryopreserved with a clinical-grade procedure and important cell populations are not only preserved but also enriched by the process.
We found for the first time that testicular tissue and cells from patients undergoing sexual reassignment can be successfully cryopreserved and important cell populations can be enriched by the cryopreservation process.
The combined results confirm the sensitivity and flexibility of the RNA-Amp™ method and demonstrate the suitability of the approach for identifying clinically relevant signatures in rare, biologically important cell populations.
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