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Human MSCs attach to various substrates through cell adhesion proteins, and osteopontin is an important cell adhesion protein for both MSCs and osteoblasts found in bone.
It was found that EGMP-containing PEGDA hydrogels are able to sequester the important cell adhesion protein osteopontin, and these hydrogels promoted hMSC adhesion and spreading.
Although these results have clarified the distinct molecular interactions at the BBB, little is known about the temporal regulation pattern of these important cell adhesion molecules during the entire course of AT-EAE.
This is supported by evidence that Dscam may respond to a non-Netrin cue [16] and the recent identification of turtle as an important cell adhesion molecule that interacts with mutations in Netrin or fra to further reduce commissure formation [18].
CD44 is an important cell adhesion molecule with a variety of tissue-dependent functions [ 2].
E-cadherin is considered to be the most important cell adhesion molecule in the mammary gland.
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Koike and colleagues have shown that hypoxic human colon cancer cells remarkably overexpress syndecan-4 and α5 integrin, which are important cell-adhesion molecules involved in the enhanced adhesion of cancer cells to fibronectin [ 82].
E-cadh is one of the most important cell-cell adhesion receptors involved in tissue morphogenesis and maintenance of epithelial tissue integrity [12], [53].
Several studies have investigated whether local concentration or global concentration of cell-adhesive ligand is more important for cell adhesion and spreading.
A large-scale analysis of lineage-specific cell-surface protein expression would also identify those proteins actually involved in important cell signaling, cell adhesion and cell migratory processes during early development and stem cell formation.
CD44 is a transmembrane glycoprotein which functions primarily as an important cell surface adhesion molecule interacting with hyaluronan [ 5].
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