Sentence examples for important bleeding was from inspiring English sources

Meta-analyses showed that the incidence of clinically important bleeding was significantly lower in the PPI group as compared with H2RA (OR 0.45, 95% CI (0.21, 0.9), P = 0.04).

We found that clinically important bleeding was associated with an increase in mortality (absolute risk increase, 20 30%; RR increase, 1 4) and an increased length of ICU stay (approximately 4 8 days) using three different analytic methods.

We found that patients who bled earlier in their ICU stay had a lower risk of dying than patients who bled later (P = 0.02): the RR of mortality associated with clinically important bleeding was 0.4 (95% CI = 0.06 2.0) at 2 weeks, 1.6 (95% CI = 0.6 4.0) at 3 weeks, and 7.4 (95% CI = 1.7 32.2) at 4 weeks.

Using the matched cohort method, we found that the attributable length of ICU stay for patients with clinically important bleeding was not significantly increased, at 0.6 days (95% CI = -5.1 to 6.3 days) in non-survivors and 3.8 days (95% CI = -0.01 to 7.6 days) overall.

The advantages and disadvantages of several approaches to estimating the attributable mortality and length of intensive care unit stay associated with clinically important bleeding are presented (a crude comparison of bleeding and non-bleeding patients, and the three methods used in these analyses).

Prevention may be unnecessary in populations in which clinically important bleeding is documented to be very rare, [ 40], and thus bleeding prophy-laxis strategies may need to be customized to different settings.

For example, the incidence of clinically important bleeding is difficult to estimate since many of these studies did not distinguish between various types of occult (microscopic), overt (macroscopic), and clinically important bleeding [ 9, 10, 11, 12, 13, 14].

While there have been few controlled studies of stress ulcer prophylaxis in non-ICU settings, indirect evidence (i.e. routine discontinuation of prophylaxis in published investigations) suggests that most experts believe the risk of clinically important bleeding is too low to justify continued prophylaxis.

15 In a surgical setting, (1) the efficacy end point, a composite of deep vein thrombosis (DVT), pulmonary embolism, or related death, occurs in orthopedic surgery patients with substantially greater frequency than stroke in AF patients, and (2) the frequency of clinically important bleeding is sufficiently high to assess dose dependence.

Using the matched cohort method, the RR of mortality attributable to clinically important gastrointestinal bleeding was significant (RR = 2.9, 95% CI = 1.6 5.5).

In addition, the end point of 'clinically important GI bleeding' was not homogeneous in the trails included in the study [ 12].