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They concluded that there was no clear agent of choice for prophylaxis based on efficacy considerations (ie ability to prevent clinically important bleeding), but sucralfate might have advantages in terms of adverse effects because it was associated with a lower incidence of pneumonia compared with histamine-blocking medications.
Similar(59)
In heterogeneous ICU patients, clinically important bleeding rates are low, but high risk groups are those requiring mechanical ventilation for longer than 48 hours [ 4] or those who have a coagulopathy [ 2, 4, 5, 6, 7].
Subdural hematomas are an important bleeding complication of antithrombotic therapies.
Factor VIII (FVIII) is a multidomain protein that is deficient in hemophilia A, a clinically important bleeding disorder.
It is controversial whether use of SSRIs is a cause of clinically important bleeding; results from observational studies have been equivocal.
In this survey, only 10% of the surveyed institutions evaluated the incidence of clinically important bleeding.
Three parallel analyses were conducted for the length of ICU stay attributable to clinically important bleeding.
Only 27% of the institutions surveyed evaluated the incidence of clinically important bleeding.
Aspirin therapy was associated with a higher incidence of clinically important bleeding events.
For example, the incidence of clinically important bleeding is difficult to estimate since many of these studies did not distinguish between various types of occult (microscopic), overt (macroscopic), and clinically important bleeding [ 9, 10, 11, 12, 13, 14].
Both microscopic and macroscopic (ie overt) bleeding are relatively common findings in published studies, but there is no well documented relationship between such bleeding and the incidence of clinically important bleeding complications (eg hemodynamic instability, perforation, need for transfusion).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com