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Regulation of UCP2 by Sirt1 may also be an important axis that is dysregulated by excess fat to contribute to obesity induced diabetes [ 10].
The Renin-Angiotensin-Aldosterone System (RAAS) has been closely related with the deleterious effect seen in patients with cardiovascular diseases, turning RAAS into an important axis that could be intervened to reduce disease [ 17, 18].
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In other cases, though, site composition was distinguished along a second, but equally important, orthogonal axis that was more reflective of the effects of geomorphic history on edaphic conditions.
Environmental and metabolic factors are important regulators of the neuroendocrine axis that affects growth and development of puberty; however these influences are superimposed upon substantial genetic control [5].
Follistatin, a glycoprotein forming part of the inhibin-activin-follistatin axis that plays an important role in follicular development within the ovary, is highly overexpressed in ovary (zsex = -16.7) but no significant bias appears in the rest of tissues analyzed.
Another important axis of differentiation is that of social strata.
The position of the helicoplacoid mouth, to one side of the animal, with the anus at one end, indicates that this important axis has shifted away from being front to back and was more echinoderm-like than all earlier members of the lineage (Smith 2008).
From our studies, we clearly demonstrate that an important axis exists between airway and tissue macrophage subsets.
At the G20 summit, some commentators argued that the most important axis was a "G2" of the US and China.
This has created added duties, which include forming part of an important axis in defence.
The second most important axis (axis 2) clearly defines the split between the Crenarchaeota and Euryarchaeota.
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