Sentence examples for important antigenic changes from inspiring English sources

Antigenic drift of influenza A hemagglutinin is probably the best-studied evolutionary process in any virus, yet both the timing and amino acid location of changes that lead to important antigenic changes (16) in any particular strain remain difficult to predict (17).

The antigenic drift of influenza A haemagglutinin is a well-studied evolutionary process, in terms of both the timing and the amino acid location of changes that lead to important antigenic variation.

The genetic changes found in this investigation, mainly those characterized in important antigenic sites, justify the continued efforts to monitor the emergence of new viral variants in an attempt to reduce the burden that they may cause to public health.

The principal evolutionary mechanism of influenza virus is by antigenic drift, creating small progressive antigenic changes in the hemagglutinin and neuraminidase surface antigens [42].

Conserved changes in the gene coding for VP7 were identified in two important antigenic regions (regions D and F).

Among these viruses, influenza is the only one with frequent antigenic changes.

Annual influenza epidemic and periodic pandemic outbreaks result from continuous antigenic changes within HA and NA proteins, known as antigenic drift and shift.

Yet another model proposes these antigenic changes arise from shifts in host population immunity [44].

This program continuously monitors genetic and antigenic changes in influenza viruses circulating in Canada.

We confirmed that amino acid substitutions associated with the antigenic changes gradually accumulated on the globular head region of HA and were distributed over four distinct antigenic sites.

H3N2 antigenic drift is characterized by stepwise antigenic changes that occur every 2 8 years [5], against a background of a relatively steady rate of amino acid substitutions.