Exact(2)
Despite a thorough investigation by Air New Zealand (the Black Box and Cockpit Voice Recorder proved inconclusive) an impenetrable mystery seems destined to hang forever over the fate of that book (inscribed with my name, many important annotations and the email address of the young American woman I had sat next to on the plane).
In avoid of missing important annotations, we use a parameter 25% instead of the top three rule.
Similar(58)
Therefore, using a single ontology to annotate the functional relationship of gene products will likely miss important annotation information provided by other ontologies.
We believe that failing to detect an important annotation would have far more severe consequences than assigning a wrong annotation.
Since the only additional information available to the diffusion method is global network information, i.e. information not available in matches in the local neighborhood, we conclude that the global topology of the network provides important annotation information and this information is tapped into by the diffusion mechanism embodied in the cost function (eq. 1).
An important annotation to these findings is the absence of a gold standard to diagnose LTBI.
While interpreting the results of ConsensusPathDB, we have searched for 20 most important annotation clusters that were defined by DAVID functional enrichment clustering [ 53].
Variants in the genome for which the sequence is conserved across species have been proposed as an important annotation class for prioritization and are potentially causative [ 33, 47].
We provide examples on how it allows researchers, through a user-friendly web interface, to work on novel and publicly available SNPs to extract important annotation and genotyping information.
In metagenomic projects, an important annotation step is to query the reads or Open Reading Frames (ORF) against reference databases of known genomes, DNAs or proteins with an alignment program such as basic local alignment search tool (BLAST) [ 27], BWA [ 65], BLAT [ 66], FR-HIT [ 67] or Rapsearch [ 68].
After manual review, out of these, only 80 were assigned "important publication" annotations.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com