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I think very early education is incredibly important, and primary school teachers are the great unsung heroes.
Concept is on the most important and primary elements during the design process.
Based on clinical data, the development of efficient methods capable of inducing strong T-cell responses is an important and primary step toward the development of immunotherapeutics against chronic HBV infection.
Macrophages constitute an important and primary line of defense against any infection.
ER status is the most important and primary determinant of treatment options through targeting ER functions by TAM or synthesis by aromatase inhibitors [ 23].
Our earlier studies have, however, not confirmed an important and primary role of insulin in physiologic resynthesis of skeletal muscles during animal starvation-refeeding experiments [ 4], as well as in human skeletal muscles, where insulin only attenuated break down of non-myofibrillar proteins [ 2].
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In the age of genomics, both genetics of common disorders and large-scale applications in screening will become increasingly important, and primary-care health workers will have to be prepared to discuss these issues with their clients.
Although this undoubtedly is an important and perhaps primary function of the regulations, they also have an important role in limiting the extent to which investigators harm research subjects, and limiting the extent to which society supports and benefits from a process which exploits others.
For locally advanced and metastatic PCa, androgen deprivation therapy (ADT) remains the most important and the primary treatment [7], which can lead to symptomatic improvement and a reduction in serum prostate specific antigen (PSA) levels in most patients.
More importantly, such indispensable aspect of care is clearly fundamental in the future of care where health promotion and health education activities are more important and the primary units of interventions are households.
In this section, we recall some important notation, definitions, and primary results together with references.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com