Sentence examples for important activators of from inspiring English sources

Other important activators of PAR-1 include activated protein C (APC) and matrix metalloproteinase-1 (MMP-1); whereas trypsin and human mast cell tryptase activate PAR-2 and trypsin and cathepsin G activate PAR-4.

In addition to their role in cell growth and differentiation, Erk 1/2 and p38 serve as important activators of the immune response in non-phagocytic cells through the activation of AP-1.

Such motifs in extracellular matrix proteins are important activators of integrin signalling.

Overall our data fit into an emerging picture revealing that exosomes, and their major component Hsp70 are important activators of many functions related to the pro-inflammatory response.

Indeed, monocytes from FMF patients in remission fail to induce LPS homologous tolerance and exhibit heightened sensitivity to bacterial endotoxin [72], one of the important activators of the cryopyrin/NALP3/CIAS1 inflammasome [73].

Indeed, monocytes from FMF patients in remission fail to induce LPS homologous tolerance and exhibit heightened sensitivity to bacterial endotoxin [34], one of the important activators of the cryopyrin/NALP3/CIAS1 inflammasome [35].

For example, the Ppp2r2c transcript, encoding an important activator of β-catenin (CTNNB1) transcriptional activity (Gordon and Nusse 2006), was increased in WT uteri by E2, as well as by BPA and HPTE, but was not changed in KIKO mice by any of the treatments.

Another enzyme called poly(ADP-ribose) polymerase 1 (PARP-1), a mediator of programmed necrosis activated by oxidative stress, is an important activator of caspase-independent cell death (Zhang et al. 1994).

IFN-γ, produced predominantly by activated CD4 Th1 and CD8 cytotoxic T lymphocyte (CTL) and NK cells in response to IL-12 signaling, is an important activator of macrophages that enhances their microbicidal activity against intracellular pathogens [ 25, 26].

(ADP-ribose) polymerase-1 (PARP) activity has been shown to be an important activator of caspase-independent apoptosis and involved in the release of AIF, which eventually leads to high molecular weight DNA fragmentation, MOMP and the release of cytochrome c [37].

Interestingly, PPARα is an important activator of fatty acid catabolism and may be activated not only by AMPK, but also by fatty acids, fibrates, and eicosanoids [ 48].