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The topics which were acknowledged by multiple interviewees or whose importance was supported by complementary data are reported in the results section.
Internal consistency was also good for deficiency heat and deficiency cold which are most important for differential diagnosis of KDS-Yin and KDS-Yang [ 1, 2, 16]; and their importance was supported by a discriminant analysis studying the symptom characteristics of KDS-Yin and KDS-Yang [ 28].
In contrast, internal consistency was good for Kidney-Essence deficiency and Kidney-Qi deficiency which are important domains of KDS-Yin and KDS-Yang, respectively [ 1, 2, 16]; and their importance was supported by that these two domains individually accounted for about 25% of the variance in the EFA data set and that of other domains was less than 10%.
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Their importance is supported by the increasing percentage of approved new drug entities that are, in fact, prodrugs.
Although these increases in AER are small in magnitude, their clinical importance is supported by data showing that AER in what has been considered the "normal range" (<30 mg/24 h) confers independent and significant risk for cardiovascular events and/or death in multiple studies including population-based (8) and cardiac disease (9) cohorts.
It is obviously impossible to examine in detail functions and potential pathophysiological roles of all of the identified alterations, therefore our discussion will focus on selected genes whose expression was found markedly altered and whose potential importance is supported by the existing literature.
Its importance is supported by observations that the group with relatively and absolutely shortest necks, the Dicraeosauridae and Rebbachisauridae were significantly smaller than all other sauropod groups (Upchurch et al., 2004; Sereno et al., 2007), i.e. that neck length scales with positive interspecific allometry (Parrish, 2006).
This region contains an extended helix at the beginning of the α-helical domain and its importance is supported by the identification of several disease-causing mutations (S315F, L316F, L316W, Q324L), which were predicted to destabilize the α-helical segment and disrupt its hydrogen bonding with subdomain A [ 16- 18].
The importance of TRAIL was supported by experiments in nude mice where the lack of functional T cells could be compensated by agonistic anti-TRAIL-receptor (DR5) antibodies.
The importance of phosphorylation was supported by visualizing extensive interactions between the N- and C-terminal domains in the DevR structure that mask the DNA binding domain.
The importance of Gln70 was supported by results of the in vitro GAP assay, in which Q70E or Q70N mutants of Rab1 did not significantly affect the activity of VirA but were completely resistant to LepB-catalyzed GTP hydrolysis.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com